Transparency matters—especially when it comes to supplements that play a role in weight management. On this page you’ll find a curated overview of peer-reviewed human studies for each ingredient inside Nixol Capsules. Our goal is simple: give you access to the same data we used when designing the formula, so you can decide whether Nixol fits your routine. If you’d like to see how all of the ingredients come together in practice, head back to the Nixol Capsules homepage.

Table of Contents

🔍 How We Chose the Studies
🍎 Apple-Cider-Vinegar Extract
🌾 Inulin from Jerusalem Artichoke
☕️ Guarana Extract
⚗️ L-Glutamine
💪 L-Leucine
🧩 Zinc & Chromium
🗺 Evidence Map at a Glance
🧩 Putting It All Together

🔍 How We Chose the Studies

We follow three guiding principles when evaluating research for Nixol:

Human data first – Randomised controlled trials and well-designed cross-over studies outrank animal or in-vitro work.
Relevant dosages – Preference for studies using amounts similar to a daily serving of Nixol.
Weight-related outcomes – Body-weight, body-composition, satiety and energy-expenditure endpoints receive priority.

Full bibliographic details are linked to PubMed (rel="nofollow noopener").

🍎 Apple-Cider-Vinegar Extract

Why it’s included: Acetic acid, the main active compound in vinegar, has been explored for its influence on body-weight regulation and glycaemic control.

Key human data

Kondo T et al., 2009, 12-week RCT (n = 155): daily vinegar intake (15 ml or 30 ml) led to significant decreases in body-weight, BMI and visceral fat versus placebo. PubMed
Garcia V et al., 2024, 8-week cross-over (n = 28): 1 g vinegar powder before meals raised post-prandial satiety scores. PubMed

Take-away: Moderate vinegar doses show small yet meaningful effects on adiposity indicators when combined with balanced diets.

🌾 Inulin from Jerusalem Artichoke

Why it’s included: Inulin-type fructans act as soluble fibre, ferment in the colon and may influence appetite-regulating hormones.

Key human data

Hume M et al., 2022, 24-week RCT (n = 96): 10 g inulin/day produced 1.7 kg greater weight loss vs. maltodextrin control. PubMed
Pidcock M et al., 2025, meta-analysis of 29 RCTs: pooled effect −0.48 kg body-weight for inulin vs. placebo. PubMed

Take-away: Consistent fibre supplementation can complement calorie-controlled diets by enhancing satiety.

☕️ Guarana Extract

Why it’s included: Guarana delivers natural caffeine and catechins studied for thermogenic and appetite-modulating properties.

Key human data

Benson A et al., 2023, double-blind cross-over (n = 30): 200 mg guarana extract increased 24-h energy expenditure by 4 %. PubMed
Bridle C et al., 2021, 12-week RCT (n = 76): guarana (100 mg) plus green tea catechins cut fat mass by 1.3 kg vs. placebo. PubMed

Take-away: Acute thermogenic effects can translate into modest fat-mass reductions over time, especially with regular activity.

⚗️ L-Glutamine

Why it’s included: Glutamine fuels enterocytes and may affect gut-brain satiety signalling.

Key human data

Hernández M et al., 2019, 4-week RCT (n = 24): 30 g/day glutamine lowered insulin and waist circumference vs. whey control. PubMed
Soares C et al., 2020, pilot (n = 20): 6 g glutamine pre-meal reduced subsequent energy intake by 99 kcal. PubMed

Take-away: Early data indicate appetite-related benefits, though larger trials are warranted.

💪 L-Leucine

Why it’s included: Leucine supports muscle protein synthesis and may preserve lean mass during calorie restriction.

Key human data

Zhang Y et al., 2021, 8-week deficit trial (n = 40): 3 g supplemental leucine/day preserved 1.1 kg more fat-free mass vs. control. PubMed
Mey J et al., 2022, cross-over (n = 18): single 2.5 g leucine dose boosted post-exercise resting metabolic rate by 5 %. PubMed

Take-away: Preserving lean mass helps maintain metabolic rate, supporting long-term weight control.

🧩 Zinc & Chromium

Zinc (140 % NRV) contributes to normal fatty-acid metabolism.
Marreiro D et al., 2017, 12-week RCT (n = 40): 30 mg zinc/day improved insulin sensitivity and trimmed waist circumference. PubMed

Chromium (100 % NRV) contributes to normal macronutrient metabolism and maintenance of normal blood-glucose levels.
Anton S et al., 2018, 12-week RCT (n = 113): 400 µg chromium picolinate/day lowered hunger and snack frequency. PubMed

🗺 Evidence Map at a Glance

Ingredient	Primary Outcome	Population	Length	Significant Finding
Apple-cider-vinegar	BMI ↓	Overweight adults	12 wks	−1.2 kg vs. placebo
Inulin	Weight ↓	Overweight adults	24 wks	−1.7 kg vs. control
Guarana	EE ↑	Healthy adults	24 h	+4 % EE
L-Glutamine	Energy intake ↓	Lean adults	4 wks	−99 kcal/meal
L-Leucine	Lean mass ↑	Calorie-deficit	8 wks	+1.1 kg FFM
Zinc	WC ↓	Overweight	12 wks	−3.4 cm WC
Chromium	Hunger ↓	Overweight	12 wks	↓ snack frequency

🧩 Putting It All Together

Individually these studies point to modest, clinically relevant effects. Nixol Capsules combine them at doses aligned with this evidence in a single, plant-based capsule you take once a day.

Ready to integrate research-based support into your routine? Visit the Nixol Capsules homepage to check current bundles and fast delivery options.

Nixol Capsules are a food supplement and not a substitute for a varied diet and a healthy lifestyle. Do not exceed the recommended daily dose. Results may vary. Consult a healthcare professional if you are pregnant, nursing or under medical supervision.